An in vivo evaluation of induction of abnormal sperm morphology by some anthelmintic drugs in mice
Identifieur interne : 002415 ( Main/Exploration ); précédent : 002414; suivant : 002416An in vivo evaluation of induction of abnormal sperm morphology by some anthelmintic drugs in mice
Auteurs : O. A Otubanjo [Nigeria] ; A. A Mosuro [Nigeria]Source :
- Mutation Research - Genetic Toxicology and Environmental Mutagenesis [ 1383-5718 ] ; 2001.
English descriptors
- KwdEn :
- Teeft :
- Abnormal sperm heads, Abnormality, Albendazole, Anthelmintic, Anthelmintic drugs, Dose levels, Exposure periods, Genetic material, Germ cells, Ibadan, Levamisole, Mebendazole, Mosuro, Mosuro mutation research, Mutagenic, Mutagenicity, Mutat, Mutation, Negative controls, Nigeria, Niridazole, Nitrosated metabolites, Other workers, Otubanjo, Pamoate, Pyrantel, Pyrantel pamoate, Pyrvinium, Pyrvinium pamoate, Salmonella typhimurium, Sperm, Sperm head, Sperm head shape, Sperm heads, Spermatogenesis, Thiabendazole.
Abstract
Abstract: Using the murine sperm-head abnormality test, the mutagenicity of pyrantel pamoate, levamisole, albendazole, mebendazole and niridazole was evaluated. Pyrantel pamoate and niridazole induced increases in sperm-head abnormalities statistically significant over the negative controls at all the dose levels that were considered; the induction was dose-dependent indicating that both drugs might be mutagenic. Levamisole, albendazole, mebendazole and thiabendazole, all were unable to induce statistically significant increases in sperm-head abnormalities over the negative controls at all the dose levels tested; there was no correlation between dose level of administered drugs and incidence of abnormal sperms, indicating that the drugs might not be mutagenic.
Url:
DOI: 10.1016/S1383-5718(01)00250-9
Affiliations:
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A" last="Otubanjo">O. A Otubanjo</name><affiliation></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Nigeria</country><wicri:regionArea>Department of Zoology, Marine Biology and Fisheries, University of Lagos, Lagos</wicri:regionArea><wicri:noRegion>Lagos</wicri:noRegion></affiliation></author><author><name sortKey="Mosuro, A A" sort="Mosuro, A A" uniqKey="Mosuro A" first="A. A" last="Mosuro">A. A Mosuro</name><affiliation wicri:level="4"><country xml:lang="fr">Nigeria</country><wicri:regionArea>Department of Zoology, University of Ibadan, Ibadan</wicri:regionArea><orgName type="university">Université d'Ibadan</orgName><placeName><settlement type="city">Ibadan</settlement><region type="region">État d'Oyo</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Mutation Research - Genetic Toxicology and Environmental Mutagenesis</title><title level="j" type="abbrev">MUTGEN</title><idno type="ISSN">1383-5718</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="2001">2001</date><biblScope unit="volume">497</biblScope><biblScope unit="issue">1–2</biblScope><biblScope unit="page" from="131">131</biblScope><biblScope unit="page" to="138">138</biblScope></imprint><idno type="ISSN">1383-5718</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1383-5718</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anthelmintic exposure</term><term>Mice</term><term>Mutagenicity</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Abnormal sperm heads</term><term>Abnormality</term><term>Albendazole</term><term>Anthelmintic</term><term>Anthelmintic drugs</term><term>Dose levels</term><term>Exposure periods</term><term>Genetic material</term><term>Germ cells</term><term>Ibadan</term><term>Levamisole</term><term>Mebendazole</term><term>Mosuro</term><term>Mosuro mutation research</term><term>Mutagenic</term><term>Mutagenicity</term><term>Mutat</term><term>Mutation</term><term>Negative controls</term><term>Nigeria</term><term>Niridazole</term><term>Nitrosated metabolites</term><term>Other workers</term><term>Otubanjo</term><term>Pamoate</term><term>Pyrantel</term><term>Pyrantel pamoate</term><term>Pyrvinium</term><term>Pyrvinium pamoate</term><term>Salmonella typhimurium</term><term>Sperm</term><term>Sperm head</term><term>Sperm head shape</term><term>Sperm heads</term><term>Spermatogenesis</term><term>Thiabendazole</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Using the murine sperm-head abnormality test, the mutagenicity of pyrantel pamoate, levamisole, albendazole, mebendazole and niridazole was evaluated. Pyrantel pamoate and niridazole induced increases in sperm-head abnormalities statistically significant over the negative controls at all the dose levels that were considered; the induction was dose-dependent indicating that both drugs might be mutagenic. Levamisole, albendazole, mebendazole and thiabendazole, all were unable to induce statistically significant increases in sperm-head abnormalities over the negative controls at all the dose levels tested; there was no correlation between dose level of administered drugs and incidence of abnormal sperms, indicating that the drugs might not be mutagenic.</div></front></TEI><affiliations><list><country><li>Nigeria</li></country><region><li>État d'Oyo</li></region><settlement><li>Ibadan</li></settlement><orgName><li>Université d'Ibadan</li></orgName></list><tree><country name="Nigeria"><noRegion><name sortKey="Otubanjo, O A" sort="Otubanjo, O A" uniqKey="Otubanjo O" first="O. A" last="Otubanjo">O. A Otubanjo</name></noRegion><name sortKey="Mosuro, A A" sort="Mosuro, A A" uniqKey="Mosuro A" first="A. A" last="Mosuro">A. A Mosuro</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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